The non-human primate experimental glaucoma model

The Non-human Primate as a Model of Human Parkinsonism

Intraocular pressure magnitude and variability as predictors of rates of structural change in non-human primate experimental glaucoma.

The purpose of this study is to determine the effects of intraocular pressure (IOP) mean, maximum and variability on the rate of structural change in experimental glaucoma. Data were taken retrospectively from 59 non-human primates involved in ongoing studies of experimental glaucoma. IOP was measured by tonometry every 1-3 weeks, and these readings split into non-overlapping fixed-length windo...

Macular Structure and Function in Nonhuman Primate Experimental Glaucoma

PURPOSE To evaluate structure and function of macular retinal layers in nonhuman primate (NHP) experimental glaucoma (EG). METHODS Twenty-one NHP had longitudinal imaging of macular structure by SDOCT, 16 also had recordings of function by multifocal ERG. The average thickness over 15° was derived for seven individual SDOCT layers: macular nerve fiber layer (m-NFL), retinal ganglion cell laye...

A Non-Human Primate Model for Gluten Sensitivity

BACKGROUND AND AIMS Gluten sensitivity is widespread among humans. For example, in celiac disease patients, an inflammatory response to dietary gluten leads to enteropathy, malabsorption, circulating antibodies against gluten and transglutaminase 2, and clinical symptoms such as diarrhea. There is a growing need in fundamental and translational research for animal models that exhibit aspects of...

Non-Human Primate Model of Kaposi's Sarcoma-Associated Herpesvirus Infection

Since Kaposi's sarcoma-associated herpesvirus (KSHV or human herpesvirus 8) was first identified in Kaposi's sarcoma (KS) lesions of HIV-infected individuals with AIDS, the basic biological understanding of KSHV has progressed remarkably. However, the absence of a proper animal model for KSHV continues to impede direct in vivo studies of viral replication, persistence, and pathogenesis. In resp...